益气养阴活血汤联合西药治疗气阴两虚兼血瘀型糖尿病肾病疗效观察

Effect of Yiqi Yangyin Huoxue Tang Combined with Western Medicine in Treating DN with Qi-yin Deficiency and Blood Stasis Syndrome

目的:观察益气养阴活血汤联合西药治疗气阴两虚兼血瘀型糖尿病肾病患者的临床疗效。方法:抽取本院72例气阴两虚兼血瘀型糖尿病肾病患者作为研究对象,随机分为2组各36例。研究组给予益气养阴活血汤联合常规西药治疗,对照组仅给予常规西药治疗,2组均以15天为1疗程,连续治疗4疗程。比较2组的临床疗效与治疗前后血糖[空腹血糖(FBG)、餐后2 h血糖(P2h BG)及糖化血红蛋白(Hb A1c)]、肾功能指标[尿微量白蛋白排泄率(UAER)、血肌酐(SCr)及24 h尿白蛋白排泄率(24h UAE)]的情况。结果:治疗后,研究组与对照组总有效率分别为91.67%、66.67%,2组比较,差异有统计学意义(P<0.05)。2组FBG、P2h BG、Hb A1c与UAER、SCr、24h UAE水平均较治疗前降低(P<0.05),研究组各项指标值均低于对照组(P<0.05)。结论:采用益气养阴活血汤联合西药治疗气阴两虚兼血瘀型DN疗效确切,可降低血糖,改善患者的肾功能,效果优于仅用常规西药治疗。

Objective： To observe the clinical effect of Yiqi Yangyin Huoxue tang combined with western medicine in treating diabetic nephropathy（DN） with Qi-yin deficiency and blood stasis syndrome. Methods ：Selected 72 DN patients with Qi-yin deficiency and blood stasis syndrome as study objects,and divided them into two groups with 36 cases in each. The research group was given Yiqi Yangyin Huoxue tang combined with western medicine,while the control group was given western medicine only. One course of treatment lasted for 15 days,and the treatment lasted for 4 courses. Compared clinical effect, blood glucose, such as fasting blood glucose（FBG）, 2 hour postprandial blood glucose（P2hBG）, glycosylated hemoglobin（HbA1c） before and after treatment,renal function [urine albumin excretion rate（UAER）,Serum creatinine（SCr）,24 hour urine albumin excretion rate（24hUAE）] of the two groups. Results：After treatment, the total effective rate was91.67% and 66.67% in the research group and the control group respectively,the difference being significant（P〈0.05）. Levels of FBG,P2 hBG,HbA1c,UAER,SCr and 24 hUAE of the two groups were all lower than those before treatment（P〈0.05）,and every index of the research group was lower than that of the control group（P〈0.05）. Conclusion：Yiqi Yangyin Huoxue tang combined with western medicine has accurate efficacy in treating DN with Qi-yin deficiency and blood stasis syndrome,which can reduce blood glucose,improve renal function of patients,and has better effect than use routine western medicine only.