阿胶鸡子黄汤治疗甲状腺功能亢进症阴虚风动证临床观察

Clinical Observation of Ejiao Jizihuang Tang for Hyperthyroidism with Yin Deficiency and Wind Stirring Syndrome

目的:观察阿胶鸡子黄汤联合西药治疗甲状腺功能亢进症(简称:甲亢)阴虚风动证的临床疗效。方法:将本院内分泌科收治的96例甲亢患者随机分为2组各48例。对照组予口服甲巯咪唑片及普奈洛尔片治疗,观察组则在此基础上予阿胶鸡子黄汤口服进行治疗,总疗程均为12周。治疗前后均送检血清游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH),记录药物造成的不良反应,并根据临床症状体征好转情况评价临床疗效。结果:总有效率观察组优于对照组,差异有统计学意义(P<0.05);疗程结束后,2组血清FT3、FT4水平均降低,血清TSH水平均上调,差异均有统计学意义(P<0.01);与对照组比较,观察组血清FT3、FT4及TSH变化更明显,差异均有统计学意义(P<0.05);疗程中观察组不良反应发生率较对照组少,差异有统计学意义(P<0.05)。结论:阿胶鸡子黄汤联合西药治疗甲亢阴虚风动证能有效改善患者临床症状体征,改善甲状腺激素水平,减轻不良反应的发生,疗效可靠。

Objective：To observe the clinical effect of Ejiao Jizihuang tang for hyperthyroidism with yin deficiency and wind stirring syndrome. Methods：Divided 96 cases of patients with hyperthyroidism with yin deficiency and wind stirring syndrome admitted to department of endocrinology in our hospital into two groups randomly, 48 cases in each group. Both groups received thiamazole tablets and propranolol tablets orally,while the observation group additionally received Ejiao Jizihuang tang. Both groups received treatment for twelve weeks. Detected levels of serum free triiodothyronine（FT3）, serum free thyroxine（FT4） and thyroid stimulating hormone（TSH） in both groups before and after treatment. Recorded drug adverse reaction,and evaluated the clinical effect according to the improvements of clinical symptoms. Results ：The total effective rate in the observation group was superior to that in the control group, the difference being significant（P〈0.05）. After treatment,levels of serum FT3 and FT4 in both groups were decreased,while levels of serum TSH in both groups were increased,differences being significant（P〈0.01）. Changes of serum FT3,FT4 and TSH in the observation group were more obvious than those in the control group,differences all being significant（P〈0.05）. During treatment,the incidence of adverse reaction in the observation group was lower than that in the control group, the difference being significant（P〈0.05）.Conclusion： The therapy of Ejiao Jizihuang tang for hyperthyroidism with yin deficiency and wind stirring syndrome can effectively improve the clinical symptoms and signs of patients, improve the level of thyroid hormone and reduce adverse reaction,which has reliable curative effect.