白花败酱草的木脂素类化学成分研究

Lignan Constituents of Patrinia villosa (Thunb.) Juss

目的对白花败酱草的化学成分进行研究。方法通过大孔吸附树脂、Sephadex LH-20、反相HPLC等多种色谱进行分离纯化,根据理化性质和波谱数据进行鉴定。结果从白花败酱草的体积分数70%乙醇提物中分离得到了11个木脂素类化合物,分别为(7R,8S)-3,3',5-三甲氧基-4',7-环氧-8,5'-新木脂素-4,9,9'-三醇-9-O-β-D-吡喃葡萄糖苷(1),(7S,8R)-4,9'-二羟基-3,3'-二甲氧基-7,8-二氢苯骈呋喃-1'-丙醇基新木脂素-9-O-α-L-吡喃鼠李糖苷(2),(7R,8S)-二羟基脱氢二松柏醇-4-O-β-D-吡喃葡萄糖苷(3),(7S,8R)-二羟基脱氢二松柏醇-4-O-β-D-吡喃葡萄糖苷(4),7R,8S-glochidioboside(5),落叶松脂素-4-O-β-D-吡喃葡萄糖苷(6),落叶松脂素-9-O-β-D-吡喃葡萄糖苷(7),落叶松脂素-4'-O-β-D-吡喃葡萄糖苷(8),5,5'-二甲氧基落叶松脂醇-4'-O-β-D-吡喃葡萄糖苷(9),tanegool(10)和tanegool-7'-methyl ether(11)。结论所有化合物都是首次从败酱属中分离得到。

OBJECTIVE To study the chemical constituents of Patrinia villosa （Thunb.） Juss. METHODS The compounds were isolated by a combination of various chromatographic techniques including column chromatography over macroporous resin, Sephadex LH - 20, and reversed-phase HPLC. Their structures were elucidated by physiochemical property and spectral analysis. RESULTS Eleven compounds were isolated and identified as（7R,SS）-3,3＇,5-trimethoxy4＇,7-epoxy-8,5＇-neolignan-d, 9,9＇-triol-9-O-β-D-glucopyranoside （ 1 ） , massonianoside D （ 2 ） , （ 7 R, 8S ） -dihydroxydehydrodiconiferyl alcohol4-O-β-D- glucopyranoside （ 3 ） , （ 7 S, 8 R ） -dihydroxydehydrodiconiferyl alcohol4-O-13-D-glucopyranoside （ 4 ） , 7 R, 8 S-glochidioboside （ 5 ） , lariciresinol4-O-β-D-glucopyranoside （ 6 ） , lariciresinol-9-O-β-D-glucopyranoside （ 7 ） , lariciresinol-4＇-O-β-D-glucopyranoside （8） , tortoside B（9） , tanegool（10） , and tanegool-7＇-methyl ether（ 11 ）. CONCLUSION All compounds are isolated from Patrinia genus for the first time.