定痫汤加减配合拉莫三嗪治疗癫痫部分发作临床观察

Clinical Observation on Treatment of Partial Epilepsy with Dingxian Decoction Combined with Lamotrigine

目的:探讨定痫汤加减配合拉莫三嗪治疗癫痫部分发作的临床疗效。方法:选取梅州市第三人民医院2015年3月至2016年8月收治的60例癫痫部分发作患者,随机分为2组,每组30例。对照组采用拉莫三嗪治疗,观察组在对照组基础上加用定痫汤加减治疗。比较两组治疗效果。结果:对照组总有效率(73.33%)明显低于观察组(93.33%),差异有统计学意义(P<0.05);对照组不良反应发生率(33.33%)明显高于观察组(10.00%),差异有统计学意义(P<0.05);治疗3个月末,观察组拉莫三嗪用量明显比对照组减少900 mg。结论:定痫汤加减配合拉莫三嗪治疗癫痫部分发作疗效确切,能有效控制癫痫发作,降低不良反应发生率。

Objective To investigate the clinical effect of dingxian decoction with lamotrigine in the treatment of partial epilepsy. Methods 60 patients with partial seizures in our hospital from March 2015 to August 2016 were randomly divided into 2 groups, each group of 30 cases. The control group using lamotrigine treatment in the observation group, on the basis of the control group, the observation group was treated with dingxian decoction. Compare the treatment effect of the two groups. Results The total effective rate （73.33 %） in the control group was significantly lower than that in the observation group （93.33 %）, the difference was statistically significant （P 〈0.05）. The incidence of adverse reactions in the control group （33.33 %） was significantly higher than that in the observation group （10.00 %）, the difference was statistically significant （P 〈0.05）. At the end of three months, the amount of lamotrigine in the observation group was significantly reduced by 900 mg compared with the control group. Conclusion Dingxian Decoction with lamotrigine in the treatment of partial seizures of curative effect, can effectively control the seizures, reduce the incidence of adverse reactions, alleviate the patient＇s condition, it is worthy of clinical use.