慢性丙肝患者治疗前后体内尿酸变化的相关研究

Study on changes of uric acid in patients with chronic hepatitis C before and after treatment

目的探讨慢性丙肝(CHC)患者治疗前后血清尿酸水平的变化。方法选择武汉大学人民医院感染科83例CHC患者,跟踪其治疗过程。SIEMENS公司生产的ADVIA2400全自动生化分析仪测定其血清中尿酸浓度。结果 CHC患者接受治疗后,应答组患者尿酸水平高于无应答组,差异有统计学意义(t=1.89,P<0.05)。CHC患者治疗前和治疗后,男性患者尿酸水平高于女性患者,差异有统计学意义(治疗前t=2.75,治疗后t=2.65,P<0.05)。CHC患者治疗前,中年组尿酸水平低于青年组和老年组患者,差异有统计学意义(F=5.66,P<0.05);但CHC患者治疗后,中年组尿酸水平与青年组和老年组患者比较差异无统计学意义(F=1.76,P>0.05)。结论 CHC患者的治疗对其尿酸的水平有影响,应在治疗过程中予以监测。

[Objective]To explore the changes of uric acid in patients with chronic hepatitis C（CHC）before and after treatment.[Methods]83 CHC patients were collected from the Infectious Disease Department of Renmin Hospital of Wuhan University,and their treatment process were followed up. The serum uric acid concentration was tested by ADVIA2400 automatic biochemical analyzer（SIEMENS）.[Results]After treatment,the level of uric acid in response group was higher than that in non-response group,and the difference was statistically significant（t=1.89,P〈0.05）. In both before and after treatment,the levels of uric acid in male patients were higher than those in female patients,and the difference was statistically significant（t before treatment=2.75,t after treatment =2.65,P〈0.05）. Before treatment,the level of uric acid in middle age group was lower than that in youth group and elderly group,and the difference was statistically significant（F=5.66,P〈0.05）. After treatment,there was no statisti-cally significant difference in level of uric acid between middle age group and youth group,elderly group（F=1.76,P〉0.05）.[Conclusion]The treatment for CHC patients could affect the uric acid level,which should be monitored in the course of treatment.