甲状腺功能异常的无症状原发性胆汁性肝硬化分析1例

An analysis of an asymptomatic primary biliary cirrhosis cases with thyroid dysfunction

原发性胆汁性肝硬化(PBC)是自身免疫损伤介导的成人慢性胆汁淤积性肝病,病程呈进行性,不同的患者病情进展有很大差异。它是以肝内进行性非化脓性小胆管破坏伴门静脉炎症及肝脏纤维化为特点,以中年女性最为常见,男女比例1:9。PBC发病机制尚不明确,目前认为可能与环境、遗传、感染等因素相互作用有关。文献报道PBC患者可同时合并自身免疫性肝炎及其他自身免疫性疾病,如干燥综合征、甲状腺炎等。本文通过分析该患者的诊疗经过,希望能够提高医患对PBC认识程度。

Primary biliary cirrhosis （primary biliary cirrhosis, PBC） is mediated by autoimmune damage for adults with chronic cholestatic liver disease, the course of the disease is progressive, and the progression of the disease varies considerably among the different patients. It is characterized by progressive destruction of non purulent small bile duct accompanied with portal vein inflammation and hepatic fibrosis, and the middle-aged women are the most common, with a male to female ratio of 1 ： 9. Currently the pathogenesis of PBC is not clear, which may be related to environmental, genetic, infection and other factors. PBC has been reported to be associated with autoimrnune hepatitis and other autoimmune diseases, such as Sjogren＇s syndrome and thyroiditis. By analyzing the diagnosis and treatment of the patient, the understanding of PBC was expected to improve.