基于磁共振图像构建中国人脑模板

Magnetic resonance image-based Chinese brain template construction

基于磁共振图像构建的大脑模板可精确呈现脑部细节解剖结构,为脑结构和功能的评估分析提供一个标准化空间。然而,目前被广泛应用的脑模板大多是基于西方人群样本,由于中西方人脑在大小和形态上具有较大差异,此类模板用于脑成像研究的精准性欠佳,因此迫切需要构建属于国内特定人群的大脑模板。通过选取50个年龄段为19~30岁的国内成年志愿者大脑高分辨率磁共振图像构建大脑模板(CN-50),并将CN-50脑模板与MNI-152脑模板做对比评估,结果显示,CN-50脑模板较MNI-152脑模板更适用于国内人群的大脑研究。

The brain templates based on magnetic resonance images can accurately present brain anatomical details,and provide a standardized space for the analysis of brain structure and function.However,the widely used brain templates are based on western population samples.Chinese and western brains are significantly different in the size and shape due to the human population diversity.As a result,western brain templates have poor precision on Chinese neurological image studies.Therefore,a specific brain template based on Chinese populations is necessary.In the study,we selected the high-resolution brain magnetic resonance images of volunteers aging from 19 to 30 years old to construct CN-50 template.Besides,we also computed the coverage rate of 50 the whole brain and analyzed the volume of each brain to compare and evaluate CN-50 template and MNI-152 template.The results showed that CN-50 template is more suitable than MNI-152 template for the domestic population＇s brain study.