摘要
目的:观察柴芍六君子汤合乌贝散治疗难治性胃食管反流病(GERD)的临床疗效。方法:将192例GERD患者随机分为2组,治疗组96例给予柴芍六君子汤合乌贝散治疗,对照组96例给予埃索美拉唑治疗。观察比较2组临床疗效及症状评分、RDQ积分与HADS积分。结果:总有效率治疗组为95.8%,对照组为62.5%,组间比较,差异有统计学意义(P<0.01);2组症状评分、RDQ积分、HADS积分治疗前后组内比较及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:柴芍六君子汤合乌贝散治疗难治性GERD疗效确切,可改善患者症状及焦虑、抑郁状态,提高患者生活质量。
Objective:To investigate the clinical effect of Chaishao Liujunzi decoction combined with Wubei San in the treatment of refractory gastroesophageal reflux disease (GERD). Methods:A total of 192 patients with GERD were randomly divided into treatment group and control group, with 96 patients in each group. The patients in the treatment group were treated with Chaishao Liujunzi decoction combined with Wubei San, and those in the control group were given esomeprazole. The clinical outcome, symptom score, Reflux Diagnostic Questionnaire (RDQ) score, andHospital Anxiety and DepressionScale (HADS) score were compared between the two groups. Results: The treatment group had a significantly higher overall response rate than the control group (95.8 % vs 62.5 % , P 〈 0.01 ). Both groups had improvements in symptom score, RDQ score, and HADS score after treatment, and the treatment group had significantly better improvements than the control group ( P 〈 0.05 ). Conclusion : Chaishao Liujunzi decoction combined with Wubei San shows a good clinical effect in the treatment of refractory GERD, and can significantly relieve patients' symptoms, anxiety, and depression, and improve their quality of life.
出处
《湖南中医杂志》
2017年第6期10-12,共3页
Hunan Journal of Traditional Chinese Medicine
基金
2013年全国名老中医蒋士生传承工作室建设项目
全国第五批名老中医药专家学术继承项目
湖南省中医药科研计划项目(编号:201563)
关键词
胃食管反流病
中医药疗法
柴芍六君子汤
乌贝散
gastroesophageal reflux disease
traditional Chinese medicine treatment
Chaishao Liujunzi decoction
Wubei San