健脾消萎方治疗胃阴亏虚型慢性萎缩性胃炎75例临床观察

Clinical effect of prescription for strengthening the spleen and eliminating atrophy in treatment of stomach-yin deficiencytype of chronic atrophic gastritis: an analysis of 75 cases

目的:观察健脾消萎方治疗胃阴亏虚型慢性萎缩性胃炎的临床疗效。方法:将150例胃阴亏虚型慢性萎缩性胃炎患者随机分为治疗组和对照组各75例,对照组采用胃复春治疗,治疗组在对照组治疗基础上加用健脾消萎方治疗。结果:总有效率治疗组为89.3%,对照组为65.3%,组间比较,差异有统计学意义(P<0.05);治疗组血清Bc1-2和Bax治疗前后组内比较及治疗后与对照组比较,差异均有统计学意义(P<0.05)。结论:健脾消萎方治疗胃阴亏虚型慢性萎缩性胃炎疗效确切,其机制可能与抑制血清Bc1-2水平、增高Bax水平有关。

Objective：To investigate the clinical effect of prescription for strengthening the spleen and eliminating atrophy in the treatment of stomach - yin deficiencytype of chronic atrophic gastritis. Methods ： A total of 150 patients with stomach -yin defieiencytype of chronic atrophic gastritis were randomly divided into treatment group and control group,with 75 patients in each group. The patients in the control group were treated with Weifuehun, and those in the treatment group were treated with prescription for strengthening the spleen and eliminating atrophy in addition to the treatment for the control group. The treatment group had a significantly higher overall response rate than the control group （89. 3% vs 65.3% ,P 〈0. 05 ）. After treatment,both groups had significant changes in levels of serum Bcl -2 and Bax,and there were significant differeneesbetween the two groups （P 〈0. 05）. Conclusion：The prescription for strengthening the spleen and eliminating atrophy has a good clinical effect in the treatment of stomach -yin defieiencytype of chronic atrophic gastritis, which may be associated with inhibition of serum Bcl -2 level and increase of Bax level.