新型钇-羟基磷灰石骨水泥的制备及性能研究

Preparation and Properties of a Novel Yttrium-hydroxyapatite Cement

利用高温固相法合成了掺钇的磷酸四钙,将其与无水磷酸氢钙以物质的量比1∶1混合制备了钇-羟基磷灰石骨水泥(Y-HAC)。结果表明:少量钇的掺入不会改变骨水泥的水化产物,骨水泥能正常水化,水化产物为弱结晶羟基磷灰石。与纯羟基磷灰石骨水泥(HAC)相比,Y-HAC的湿态抗压强度提高了120%,干态抗压强度提高了85%。同时,钇的掺入还提高了材料的孔隙率。Y-HAC的微观结构呈现紧密结合的片状羟基磷灰石结晶体。体外释放实验表明,钇的释放量极低,说明钇-羟基磷灰石骨水泥具有较好的稳定性。Y-HAC是一种很有前途的骨组织修复材料,并可用于载药材料和骨组织工程支架材料。

The tetracalcium phosphate （TTCP） doped with yttrium was prepared by high temperature solid state method. Then the TTCP doped with yttrium was mixed with dicalcium phosphate anhydrous （DCPA） at a molar ratio of 1 ： 1 to form ytt- rium-hydroxyapatite cement （Y-HAC）. The results showed that the reaction product of Y-HAC is poorly crystalline hydroxyapatite, indicating that the addition of small amount of yttrium has not changed the hydration reaction of hydroxyapatite cement （HAC）. The wet compressive strength of Y-HAC increased 120% and dry compressive strength increased 85%, compared with that of HAC. The porosity of specimens has been augmented with the doping of yttrium. There exists some changes in crystallization morphology of Y- HAC, emerging many closely combined flaked crystals and construct a three-dimensional network structure. The in-vitro release ex- periment indicated that Y-HACs have very low release of yttrium. The Y-HAC might be a potential material for bone substitute, drug-loaded and bone tissue engineering.