控制性超促排卵治疗对母体孕期心脏结构和功能的影响

The effect of controlled ovarian hyperstimulation on cardiac structure and function during pregnancy

目的探讨控制性超促排卵对整个孕期母体心脏结构和功能的影响。方法 2014年1月~2014年12月共150名孕妇,其中人工助孕组共100例(鲜胚组和冻融组各50例),自然妊娠孕妇(正常组)50例,收集早孕与晚孕期心脏结构与功能相关数据。结果各组内比较,孕晚期孕妇舒张压较早孕稍降低、脉压差增大(P>0.05),但差异无统计学意义。右房内径、右室内径增宽,差异有统计学意义(P<0.05)。孕晚期心率较于孕早期三组均增加,但差异无统计学意义(P>0.05)。研究提示,三组间各项测量指标均无统计学差异(P>0.05)。结论体外受精-胚胎移植控制性超促排卵,短时间内超生理状态的甾体激素水平,以及冻融胚胎移植对于母体孕晚期的心脏结构及功能,并未造成不良影响。

Objective： To study the variation of maternal cardiac structure and function for controlled Ovarian Hyperstimulation （COH） pregnant women throughout the pregnancy. Methods： From January 2014 to December 2014, the data of maternal cardiac structure and function of 150 pregnant women who include 50 cases of fresh embryos transfer, 50 cases of freeze-thaw transfer, and 50 cases of normal pregnancy women were collected. Results： The comparison between within the each group, later pregnant trimester has lower diastolic blood pressure, greater pulse pressure difference than the first trimester, there was no statistically significant difference （P〉0.05） , but has wider right atrium and left ventricular interior diameter, the difference was statistically significant （P〈 0.05） . Heart rate of three groups increased in the later pregnant trimester, there was no statistically significant difference （P〉0.05） . Between groups, the measurement indexes were no statistical difference （P〉 0.05） . Conclusion： The COH that the state of the steroid hormone levels was increased in a short period of time, and the freezing and thawing embryo transplantation didi not have a negative effect to maternal cardiac structure and function of later pregnant trimester women.