DHEA对卵巢储备功能下降患者IVF周期胚胎质量的影响

The effects of dehydroepiandrosterone on embryo quality of the patients with diminished ovarian reserve in IVF cycle

目的探讨脱氢表雄酮(DHEA)对卵巢储备功能下降(DOR)患者在体外受精-胚胎移植(IVF-ET)周期中胚胎质量的影响。方法对接受IVF-ET助孕治疗的113例DOR的不孕症患者随机分为服用DHEA的研究组(n=65)和未服用DHEA的对照组(n=48)。服药3个月后接受IVF治疗,比较研究组患者服用DHEA前后卵巢储备功能指标,同时比较研究组和对照组患者IVF周期中胚胎质量和妊娠结局的差异。结果研究组的卵巢储备功能指标明显改善、Gn用量明显减少及胚胎质量、胚胎种植率和临床妊娠率明显提高(P<0.05);周期取消率和流产率呈降低趋势(P>0.05)。结论 DHEA可提高DOR患者的卵巢储备功能,提高胚胎质量,从而改善IVF周期妊娠结局。

Objective： Investigate the effects of dehydroepiandrosterone on embryo quality of the patients with diminished ovarian reserve in vitro fertilization-embryo transfer （IVF-ET） cycle. Methods： A Total of 113 DOR patients with IVF-ET treatment were randomly divided into the DHEA pretreatment group （n=65） and without DHEA pretreatment control group （n=48） . Patients in the study group took DHEA orally 3 months and would receive IVF treatment, The ovarian reserve function indexes were analyzed and compared before and after DHEA treatment in the study group, at the same time the embryo quality and pregnancy outcomes were compared between the study group and control group in IVF cycle. Results： Comparing study group with control group, the ovarian reserve function indexes were improved, the total doses of Gonadotrophin used was decreased, embryo quality, implantation rate and clinical pregnancy rate were significantly increased （all P〈0.05） ; Cycle cancellation rate and abortion rate showed a downward trend （P〉0.05） . Conclusions： Pretreatment with DHEA in patients with DOR can effectively improve the ovarian reserve function, improve the quality of embryos and pregnancy outcomes in IVF cycle.