幽门螺旋杆菌感染与上消化道疾病的关系

Relation between the Pylorus Spiral Bacillus(Hp)Infection and the Upper Alimentary Canal Disease

目的研究幽门螺旋杆茵(Hp)与上消化道疾病的关系。方法对1836例因上消化道不适来院检查的患者经 Olympus 胃镜检查胃黏膜直接涂片革兰氏染色镜检 Hp 和快速尿素酶试验检测为阳性即确定为幽门螺旋杆菌感染的患者作为研究对象,随机选取353例来院检查未查出上消化道疾病的作为对照。结果上消化道疾病Hp 感染的阳性率为63.0%,其中食管癌63.9%,贲门癌66.7%,胃癌72.9%,消化性溃疡73.6%,慢性萎缩性胃炎61.2%,浅表性胃炎60.9%;农村患者的总检出率为85.5%,城市患者为36.6%,农村明显高于城市。上消化道不同部位溃疡的 Hp 检出率除幽门溃疡为68.8%外,其他均高于70%,对照组 Hp 阳性率为14.6%。结论上消化道疾病与 Hp 感染密切相关(P<0.05);农村人口感染率明显高于城市(P<0.05);不同部位溃疡均与 Hp感染密切相关。

to study the relationship between the pylorus spiral bacillus(Hp)infection and the upper al- imentary canal disease.Methods we checked 1836 patients who feel comfortless with their upper alimentary canal with Olym- pus gastrocopy,then dyed the stomach mucous membrane by Gramstain and conducted fast carbamide enzyme trial to find py- lorus spiral bacillus.If the result is positive,we confirmed them as the patients of pylorus spiral bacillus infecting.In order to make comparison,We chose 353 patients at random who had not been found having the disease as control group.Results The positive rate of Hp infecting is 63.0%.Among them the rate of esophagus cancer is 63.9%,cardia cancer is 66.7%, stomach cancer is 72.9%,digeting ulcer is 73.6%,chronic shrinking of gastritis is 61.2%,simple form of gastritis is 60.9%;The rate of rural patient is 85.5%,the urban patient is 36.6%,which show that the rate of countryside is obvious- [y higher than that of the city.The Hp positive rate of different position in upper alimentary canal is higher than 70% except that of pylorus(68.8%),contrast group is 14.6%..Conclusion Upper alimentary canal disease is close related to Hp in- fection(P<0.05);The infection rate of the countryside is obviously higher than that of townsman(P<0.05);Ulcer in different position is closely correlative to Hp infection.