腹腔内热低渗灌注化疗预防胃癌术后腹腔复发的临床研究

Clinical Study on the Recurrence of Peritoneal Cavity with Hyperthemic Peritoneal Perfusion after Gastric Cancer

目的评价腹腔内热灌注化疗对侵及浆膜的进展期胃癌根治术后预防腹腔复发的疗效。方法进展期胃癌96例,随机分成两组,52例接受术中、术后早期腹腔内热低渗灌注化疗;44例作为对照组接受常温双蒸水冲洗腹腔和 FM 方案静脉化疗。结果治疗组和对照组3年生存率分别为61.5%、45.5%,腹腔复发率分别为5.2%、30%。结论腹腔内热灌注化疗可以预防侵犯浆膜的进展期胃癌术后腹腔复发,是一种安全、有效的治疗手段。

Objective To evaluate the effect of preventing the recurrence of peritoneal cavity with hyperthemie peri- toneal perfusion after resection of gastie cancer whieh had penetrated the serosa and visceral peritoneum.Methods 96 cases were devised into treatment group and control group,52 cases were treated with hyperthemic peritoneal perfusion after resec- tion of advance gastic eaneer while 44 cases only accepted distillate to flush the belly cavity and with the FM project vein chemotherapy.Results The three-year survival rate in treatment group and control group were 61.5% and 45.5%.The recurrence of peritoneal cavity in treatment group and contrl group were 5.2% and 30%.Conclusion Hyperthemie perito- neal peffusion is a safe and effeetive method for preventing the recurrence of peritoneal cavity after resection of invading serosa from advanced gastric cancer.