影响慢性乙型肝炎病毒感染临床结局的宿主因素

Host factors influencing the clinical outcome of chronic hepatitis B virus infection

慢性乙型肝炎病毒（HBV）感染者不同的临床结局是病毒、宿主及环境因素之间相互作用所致，是多种因素综合作用的结果。宿主方面的因素包括感染病毒时的年龄、性别、个人行为、宿主遗传因素（基因多态性）及肠道微生态等。这些因素通过多种机制，直接或间接地影响慢性HBV感染者的临床结局。因此在慢性HBV感染者的管理中，不仅要重视病毒的控制，同时要关注宿主因素的影响，以便最大限度地改善患者的临床结局。

The clinical outcomes of chronic HBV infection are influenced by the interaction between virus, host and environmental factors. Several factors of host include age, sex, individual behavior, host genetic polymorphism and intestinal microflora, directly or indirectly affect the clinical outcome of chronic HBV infection. Therefore, in the management of chronic HBV infection, more attention need to be paid not only to antiviral therapy, but also to the impact of host factors in order to maximally improve the prognosis of patients.