首发抑郁症患者血清FGF-22水平测定及相关研究

Determination of serum fibroblast growth factor-22 level in patients with first episode depression and its related research

目的探讨成纤维细胞生长因子-22（FGF-22）在首发抑郁症患者中的表达情况及与5-羟色胺（5-HT）、白介素-1β（IL-1β）、汉密尔顿抑郁量表（HAMD）评分之间的相关性，为进一步探讨抑郁症发病机制提供依据。方法选择江苏大学附属医院精神科门诊自2015年6月至2016年6月接诊的首发抑郁症患者90例为抑郁组，同期招募的90名健康志愿者（均为该院工作人员或家属）为健康对照组。检测2组受试者FGF-22、5-HT、IL-1β水平及HAMD评分。分析抑郁组患者FGF-22与HAMD量表评分及血清5-HT、IL—1β水平的相关性。结果（1）首发抑郁症患者治疗前血清FGF-22水平为（180．44±17．02）ng／mL，明显低于健康对照组的（200．74±16．63）ng／mL；HAMD评分为（17．84±5．92）分，明显高于健康对照组的（1．88±2．67）分，差异均有统计学意义（P〈0．05）。（2）治疗后患者血清FGF-22水平达到（195．74±19．57）ng／mL，显著高于治疗前；HAMD评分下降至（7．64±4．09）分，显著低于治疗前，差异均有统计学意义（P〈0．05）。（3）抑郁症患者血清FGF-22水平与HAMD评分呈负相关关系（r=-0．644，P=-0．000），与5-HT呈正相关关系（r=0．718，P=0．000），与IL-1β呈负相关关系（r=-0．763，P=0．000）。结论首发抑郁症患者血清FGF-22水平存在异常，可作为反应抑郁症病情较好的外周血指标。

Objective To investigate the variation of serum fibroblast growth factor-22 （FGF-22） of first episode depressive patients before and after treatment, and its relations with serotonin （5-HT） and intefleukin-1β （IL-1 β） levels and Hamilton＇s depression scale （HAMD） scores to provide assistance for further study ofpathogenesis of depression. Methods Ninety patients with first episode depression accepted treatment in our hospital from June 2015 to June 2016 and 90 healthy controls were enrolled. The serum FGF-22 level was detected and Hamilton＇s depression scale （HAMD） was performed before and after drug treatment. The relations of FGF-22 level with 5-hydroxytryptamine （5-HT） and interleukin （IL）-1β levels were analyzed. Results （1） Before treatment, the first episode depressive patients had significantly lower serum FGF-22 level （[180.44±17.02] ng/mL） and statistically higher HAMD scores （17.84±5.92） as compared with the healthy controls （[200.74±16.63] ng/mL, 1.88±2.67, P〈0.05）. （2） The serum FGF-22 level after treatment （[195.74±19.57] ng/mL） was significantly higher than that before treatment, and the HAMD scores after treatment （7.64±4.09） were significantly lower than those before treatment （P〈0.05）. （3） In the patient group, serum FGF-22 level and HAMD scores were negatively correlated （r=-0.644, P=-0.000）; serum FGF-22 level had positive correlation with 5-HT level （r=0.718, P=0.000）, and negative correlation with IL-1β level （r=-0.763, P=0.000）. ConclusionThe serum FGF-22 level is abnormal in first episode depressive patients, and it could be a good indicator of peripheral blood in response to depression, which plays an important role in the pathogenesis of depression.