重组人血白蛋白工业应用研究进展

The pharmaceutical application research progress of industrial production of Human serum albumin

人血清白蛋白(HAS)在人血浆中的含量最为丰富,是蛋白质的一种,在血浆总蛋白中所占约60%的比重,生理功能不仅重要,而且较多,同时其也是制药工业中最为重要的一种原辅助料。当前市场中销售的HSA大部分为提取与人血浆,但是血液的隐藏风险较大,这就使得基因重组人血清蛋白(r HSA)成为HSA的首选替代品。本文重点介绍了重组人血清白蛋白在工业生产上应用的研究进展。

Human serum albumin（HAS） is the most abundant in human plasma,is a protein,in the plasma total protein accounted for about 60% of the proportion of physiological function is not only important,but also more,but also the pharmaceutical industry The most important of a kind of raw auxiliary materials. Most of the HSA sold in the current market is extracted with human plasma,but the risk of blood is greater, which makes the recombinant human serum albumin（rHSA） a preferred alternative to HSA.The pharmaceutical application research progress of industrial production of rHSA were reviewed in this article.