年龄和月经周期对人血清HE4和CA125水平的影响

Efficacy of age and menstrual cycles on human serum HE4 and CA125 levels

目的探讨年龄和月经周期对人血清糖链多肽抗原125(CA125)、人附睾蛋白4(HE4)的影响。方法选择2015年1月~2016年8月于我院体检中心进行检查的健康女性160例,分为绝经前组114例,绝经后组46例,绝经前组按照年龄分为≤35岁组61例和>35岁组53例,比较绝经前组月经周期不同阶段血清CA125、HE4水平,并比较≤35岁组、>35岁组月经周期不同阶段和绝经后组血清CA125、HE4水平。结果绝经前组月经周期不同阶段血清CA125水平差异无统计学意义(P>0.05),血清HE4水平差异有统计学意义(P<0.05),其中黄体期与卵泡期差异无统计学意义(P>0.05),卵泡期、黄体期均低于排卵期,差异均有统计学意义(P<0.05);≤35岁组排卵期血清HE4水平均高于卵泡期和黄体期(P<0.05),>35岁组月经周期各个阶段血清HE4水平差异均无统计学意义(P>0.05),血清CA125水平在≤35岁组月经周期各个阶段之间、>35岁组月经周期各个阶段之间差异均无统计学意义(P>0.05)。血清CA125、HE4水平绝经期高于绝经前组月经周期各个阶段,差异有统计学意义(P<0.05)。结论健康女性血清HE4水平受到月经周期和年龄的影响,血清CA125水平受年龄的影响,临床在界定HE4、CA125的诊断阈值时应充分考虑这些因素。

Objective To investigate the effects of age and menstrual cycle in human serum carbohydrate antigen 125 （CA125） and the human epididymis protein 4 （HE4）.Methods 160 healthy women checked physical examination center in our hospital from January 2015 to August 2015 were divided into premenopause group （114 cases） and control group （46 cases）,the premenopause group was divided into two groups,age~〈35 years old （61 cases） and age〉35 years old （53 cases）. Serum CA125 and HE4 levels at different stages during menstrul cycle of the groups were compared,serum CA125 and HE4 levels of the groups ≤35 years old and〉35 years old at different stages during menstrul cycle were compared.Results There was no statistically significant difference in serum CA125 level of the premenopause group at different stages during the menstrual cycle （P〉0.05）,and there was statistically significant difference in serum HE4 level （P〈0.05）, compared the luteal phase with the follicular phase,there was not statistically significant difference （P〉0.05）,the follicular phase and the luteal phase were lower than those of the ovulation phase,the differences were statistically significant （P〈0.05）;the serum HE4 level in the ovulation phase of the women of the group ≤35 years old were higher than that of the women in the follicular phase and the luteal phase （P〈0.05）,and there were no statistically significant difference in serum HE4 level at various stages during the menstrual cycle of the group 〉35 years old at various stages during the menstrual cycle （P〈0.05）.There were no statistically significant differences in serum CA125 level at various stages during the menstrual cycle of the group≤35 years old and the group〉35 years old at various stages during the menstrual cycle.The serum CA125 and HE4 levels in the menopause were higher than those at various stages during the menstrual cycle of the premenopause （P〈0.05）,the difference was statistically significant.Conclusion The serum HE4 level of healthy women is affected by the menstrual cycle and age,the serum CA125 level is influenced by age,the clinical definition of HE4 and CA125 in diagnosis of threshold should be considered these factors.