高龄孕妇稽留流产相关因素分析及早期诊断

Related factors analysis and early diagnosis of missed abortion in elderly women

目的探索高龄孕妇稽留流产相关因素及早期诊断方法。方法选择2016年2月~2017年2月选取汕头市澄海区妇幼保健院的80例正常妊娠孕妇(对照组)、80例稽留流产患者(观察组)为研究对象,对两组受检者进行解脲支原体和沙眼衣原体感染检测以及PAPP-A含量、孕酮含量的测定后,再分析两组受检者的沙眼衣原体感染率、Uu+Ct感染率、解脲支原体感染率、PAPP-A、孕酮含量,以及不同孕龄(≤9、10、11、12、13、≥14周)时的血清PAPP含量。结果观察组受检者Uu+Ct感染率、解脲支原体感染率、沙眼衣原体感染率均高于对照组(P<0.05);观察组PAPP-A、孕酮含量均低于对照组(P<0.05);观察组各孕龄段的PAPP含量均低于对照组(P<0.05)。结论导致高龄孕妇发生稽留流产的主要原因之一为感染,而加强临床PAPP-A含量、孕酮含量的测定,能够控制流产发生率。

Objective To explore the older pregnant women missed abortion related factors and early diagnostic meth- ods.Methods 80 cases of normal pregnant women （control group） and 80 .cases of missed abortion （observation group） were selected from February 2016 to February 2017.The patients were treated with Ureaplasma Urealyticum and Chlamydia Trachomatis infection and detection of PAPP-A and progesterone were measured.The infection rate of Chlamydia Trachomatis,Uu＋Ct infection rate,Ureaplasma Urealyticum infection rate,PAPP-A and P content,and serum PAPP levels at different gestational weeks （≤9 weeks,10 weeks,11 weeks,12 weeks,13 weeks,≥14 weeks） were analyzed. Results The infection rate of Uu＋Ct, Ureaplasma Urealyticum and Chlamydia Trachomatis in the observation group was higher than that in the control group （P〈0.05）.The content of PAPP and pregnendione in the observation group was lower than that of the control group （P〈0.05）.The PAPP content of pregnant women at different gestational weeks in the ob servation group was lower than that of the control group （P〈0.05）.Conclusion Infection is one of the main reasons cause pregnant women missed abortion,and strengthen the determination of clinical PAPP-A and progesterone can control the incidence of miscarriage.