胸腺肽注射液联合阿奇霉素治疗老年慢性阻塞性肺疾病继发肺部感染的临床效果

Clinical effect of Thymosin Injection combined with Azithromycin treating the secondary pulmonary infection of chronic obstructive pulmonary disease in the elderly

目的评价胸腺肽注射液联合阿奇霉素治疗老年慢性阻塞性肺疾病继发肺部感染的临床效果。方法 2016年6月~2017年2月选取所在科室80例慢性阻塞性肺疾病继发肺部感染患者的资料进行统计分析,采用随机数字法将所有患者分为阿奇霉素组和联合用药组,每组40例。阿奇霉素组给予患者阿奇霉素治疗,联合用药组在阿奇霉素组的基础上采用胸腺肽注射液治疗。比较两组患者的治疗效果,血气分析指标改善情况、肺功能改善情况、药物不良反应发生率和痊愈时间。结果联合用药组患者的治疗效果、血气分析指标改善情况和肺功能改善情况明显优于阿奇霉素组(P<0.05);联合用药组的药物不良反应发生率低于阿奇霉素组(P<0.05);联合用药组患者的痊愈时间短于阿奇霉素组(P<0.05)。结论胸腺肽注射液联合阿奇霉素治疗老年慢性阻塞性肺疾病继发肺部感染的临床效果突出,患者的血气分析指标、肺功能改善情况改善较好,痊愈时间短,药物不良反应较少,值得临床借鉴。

Objective To evaluate the clinical effect of Thymopeptide Enteric Injection combined with Azithromycin treating the secondary pulmonary infection of chronic obstructive pulmonary disease in the elderly.Methods From June 2016 to February 2017,data of 80 patients with the secondary pulmonary infection of chronic obstructive pulmonary disease were selected and counted and analyzed.All the patients were divided into the Azithromycin group and com- bined treatment group by the random number table method,and there were 40 cases in each group.Azithromycin group was given Azithromycin treatment,and the combined treatment group was treated with Thymopeptide Enteric Injection on the basis of Azithromycin group.The treatment effect,blood gas analysis index improvement,pulmonary function improvement,adverse drug reaction rate and cure time were compared between the two groups.Results Treatment effect, blood gas analysis indicators improvement,pulmonary function improvement were better than Azithromycin group （P〈0.05）. The incidence rate of adverse drug reactions in combined treatment group was lower than that of Azithromycin group （P〈0.05）.Cure time of combined therapy group was shorter than that of the Azithromyein group （P〈0.05）.Conclusion Treatment effect of Thymopeptide Enteric Injection combined with Azithromycin in treating the secondary pulmonary infection of chronic obstructive pulmonary disease in the elderly is prominent,and the improvement of blood gas analysis and lung function indicators are better, and the cure time is short,adverse drug is few.It is worthy of clinical reference.