玻璃体液化生物力学特性及临床研究进展

Research advances in biomechanical properties and its clinical significance of vitreous liquefaction

玻璃体液化是一种与年龄相关的退行性改变,随后会进一步影响玻璃体及其周围组织的理化性质,导致多种相关眼部疾病。玻璃体液化最主要的病理改变是透明质酸逐渐耗竭和胶原网状结构塌陷,其中伴随着一系列玻璃体生物力学特性的改变。因此,本文对正常眼玻璃体的生物力学特性、玻璃体生物力学特性的测量方法、玻璃体液化形成机制和生物力学特性的改变以及玻璃体液化与眼病的关系等进行综述,以期为将来有效地减缓和治疗玻璃体液化提供思路。

Vitreous liquefaction is an age-related degenerative change,which will further alter the physicochemical properties of the vitreous and its surrounding tissues,resulting in various related eye diseases.The principal pathologic changes of that are the gradual depletion of hyaluronic acid and the collapse of collagen fibrillar network,with a series of biomechanical changes in vitreous body.This article reviews biomechanical properties of normal vitreous,the current measurements of these properties,formation mechanism and changes of biomechanics properties of vitreous liquefaction and correlation between synchesis and related ocular diseases,which provide insight into the ideas for the effective reduction and treatment of vitreous liquefaction.