润目增液汤联合人工泪液治疗干眼症的疗效

Curative effect of moisturizing eye decoction combined with artificial tears in treatment on ophthalmoxerosis

目的:观察润目增液汤联合人工泪液在干眼症治疗中的临床疗效。方法:采用临床随机对照的研究方法,将临床收集的160例320眼干眼症患者分为两组,分别为治疗组和对照组,每组各80例160眼,治疗组的患者每日口服润目增液汤,频率1剂/d,同时每日予人工泪液滴眼,频率3次/d;对照组的患者每日仅予人工泪液滴眼,频率3次/d,疗程为3mo。记录患者用药前、用药后1、3mo的干眼自觉症状,裂隙灯下观察泪膜破裂时间(BUT)、角膜荧光素染色(FL)、泪液分泌试验(SchirmerⅠtest,SⅠt)及疗效情况。结果:治疗前两组干眼患者BUT、FL、SⅠt三项差异均无统计学意义(P>0.05);用药后1、3mo,治疗组干眼BUT、FL、SⅠt及总体疗效相比于对照组,有显著的统计学差异(P<0.05)。结论:润目增液汤联合人工泪液用于干眼症治疗的疗效优于单纯使用人工泪液,并且疗效显著。

AIM： To observe the clinical effects of moisturizing eye decoction combined with artificial tears in the treatment of ophthalmoxerosis.METHODS： A randomized controlled clinical research method was employed.One hundred-sixty patients diagnosed with ophthalmoxerosis were equally divided into a treatment group and a control group.In the treatment group,patients were given one dose per day of the moisturizing eye decoction as well as artificial tear drops three times a day.The patients in the control group were treated with artificial tears drops three times a day.The course of treatment was 3mo.Dry-eye symptoms,tear break-up time（BUT） by the slit lamp,the time of tear secretion （Schirmers Ⅰ test）,corneal fluorescein staining （FL）,and curative effects were observed before treatment as well as in the first and third months after treatment.RESULTS： There were no significant differences between the two groups in terms of BUT,SⅠt,and FL before treatment （P〉0.05）.After treatment in the first and the third months,the BUT,SⅠt,FL,and curative effects were significantly different between the two groups （P〈0.05）.CONCLUSION： Moisturizing eye decoction combined with artificial tears in the treatment of ophthalmoxerosis can improve efficacy.