基于凝固浴剪切法制备多孔实心聚(乳酸-羟基乙酸)共聚物载药微球

Preparation of Poly(lactic-co-glycolic acid) Drug-Loaded Porous Solid Microspheres by Shear of Coagulation Bath Method

以聚(乳酸-羟基乙酸)为基质材料,采用一种新颖的流动凝固浴剪切法制备包载盐酸万古霉素的载药微球,并研究微球的形貌结构、粒径、包封率、载药率、体外释放性能及其影响因素。结果表明,所制备的载药微球平均粒径在15~29μm范围,微球呈现内部实心表面多孔的复合结构;微球的包封率及载药可分别在15%~75%和1.5%~9.3%范围内调控。微球制备过程中的工艺条件对微球结构形貌、包封率、载药率及释放性能有重要影响,通过调整微球的粒径,可有效减缓释药过程中的突释现象。

This reserch presented a study on preparation of poly（lactic-co-glycolic acid） （PLGA） based composite structure microspheres loaded with vancomycin hydrochloride by a novel coagulating bath and characterizations of their surface morphology, size, encapsulation efficiency, drug-loading rate, in vitro drug release properties and relative influencing factors, The results indicate that the drug-loaded microspheres, with diameters in the range of 15 -29 μm, exhibit composite construction with solid interior and porous surface. Their encapsulation efficiency and drug-loading rate could be regulated within the range of 15% -74% and 1.5% -9.3%, respectively. The preparation conditions for microspheres have significant impacts on their structure and surface morphology, encapsulation efficiency, drug-loading rate and release properties. It is demonstrated that the sudden release of the drug can be improved by controlling the diameter of drug-loaded mierospheres.