HIV-1病毒与浆细胞样树突状细胞的相互作用

Interaction of HIV-1 and plasmacytoid dendritic cells

浆细胞样树突状细胞(plamcytoid dendritic cells,pDCs)是一类可以产生大量Ⅰ型干扰素(interferonα,IFN-α)的固有免疫细胞。在人类免疫缺陷病毒(human immunodeficiency virus,HIV)急性感染期,pDCs通过分泌IFN-α抑制病毒复制并激活适应性免疫应答。在HIV慢性感染期,pDCs通过调节免疫细胞发挥免疫抑制的作用,不断破坏淋巴细胞,从而造成免疫系统崩溃,促进疾病进程。本文将就HIV-1与pDCs之间的相互作用做一综述。

Plasmacytoid dendritic cells（ pDCs） as innate immune cells can produce a large amount of interferonalpha（ IFN-α）. During the stage of acute human immunodeficiency virus（ HIV） infection,pDCs can inhibit HIV replication by releasing IFN-α and activating adaptive immune responses. In the stage of chronic HIV infection,pDCs play a role in immune suppression by regulating immunocytes and damage of the immune system by depletion of the lymphocytes. Finally,pDCs have influence on the disease progression of acquired immune deficiency syndrome（ AIDS）.