银杏内酯注射液治疗急性脑梗死的临床效果观察

Clinical effect of ginkgolide injection on acute cerebral infarction

目的探讨银杏内酯注射液治疗急性脑梗死的临床效果。方法选取我院2013年8月~2015年5月收治的178例急性脑梗死患者作为研究对象,按照随机数字表法将所有患者分为试验组92例与对照组86例,对照组患者予以常规基础治疗,试验组在常规基础治疗基础上联合银杏内酯注射液治疗,观察对比两组患者的临床治疗效果,并采取美国国立卫生研究所脑卒中评分量表(NIHSS)评估患者治疗前后的神经功能缺损情况,Barthel指数量表评估患者治疗前后日常生活能力改善情况,以及改良Rankin量表(mRS)评分评估患者治疗后神经功能恢复情况。结果试验组治疗总有效率(85.87%)显著高于对照组(74.42%),差异有统计学意义(P<0.05);治疗前两组患者NIHSS评分及Barthel指数量表评分对比差异无统计学意义(P>0.05);治疗后两组患者均明显改善,试验组改善程度优于对照组,且试验组mRS评分0~2分的患者明显多于对照组,差异均有统计学意义(P<0.05)。结论银杏内酯注射液辅助治疗急性脑梗死的临床效果显著,可以很好地改善患者神经功能缺损,提升患者日常生活能力,具有较高的临床应用价值,安全性较好,可广泛推广应用。

Objective To explore the clinical effect of ginkgolide injection on acute cerebral infarction. Methods We se- lected 178 acute cerebral infarction patients treated in our hospital from August 2013 to May 2015 as the research object. All the patients were divided into experimental group （92 cases） and control group （86 cases） according to the method of random Num- hers table. And the control group patients treated on a regular treatment, the experimental group treated on the regular treatment combined ginkgolide injection. To compared the clinical effects with the two groups of patients, and we take NIHSS score to e- valuate neurologic deficits in patients before and after treatment, take Barthel index scale to assess patients daily life ability before and after treatment as well as evaluate neurologic functional recovery after treatment in patients with mRS score. Results The study found that the experimental group total effective rate （85.87%） was significantly higher than that of control group （74.42 %）, p〈0. 05, the difference is statistically significant; NIHSS score and Barthel index scale of two groups of patients be- fore treatment had no obvious difference, p 〈0. 05, but those of two groups of patients were significantly improved after treat- ment, and the experimental group is better than that of control group. The number of mRS score 0-2 points in experimental group is significantly more than that of control group after treatment, p〈0. 05, the difference is statistically significant. Conclu- sion The treatment clinical effect of ginkgolide injection on acute cerebral infarction is remarkable, can well improve the patients neurologic deficits, and can improve patients＂ daily life ability. It has high clinical value, which can be widely applied.