β-榄香烯在抗耐药机制中的研究进展及临床展望

Research on Tumor Drug Resistance Reversal of β-elemene and Clinical Perspectives

化疗已广泛应用于肿瘤治疗。然而化疗过程中产生的耐药性是一个获得临床成功治疗的主要障碍。β-榄香烯是中药莪术中提取的天然有效抗肿瘤单体,且因其有效、安全、广谱、价廉等优点而具有良好的临床前景。最近有学者提出β-榄香烯可有效逆转化疗药物耐药,与其他化疗联合增敏等功效,现就β-榄香烯抗耐药机制及临床应用的相关研究进行综述,为榄香烯更好地应用于临床提供理论基础。

Chemotherapy has been widely used in tumor therapy.However,drug resistance occurring in the process of chemotherapy is a major obstacle to a clinical successful treatment.β-elemene is a new natural antitumor monomer extracted from Curcuma zedoaria Roscoe and has been widely used to treat malignant tumors,because β-elemene has the advantages of being safe,effective,broad spectrum and cheap.Recently,some scholars put forward β-elemene can reverse the drug resistance to chemotherapeutic drug,and sensitize tumor cell to chemotherapy.This review focuses on the β-elemene resistance mechanism and clinic application,providing better theoretical basis to clinical treatment.