中国人群饮食因素与肝癌发病关系的Meta分析

A Meta-analysis on Relationship of Dietary Factors with Liver Cancer in Chinese Population

目的探讨中国人群饮食因素与肝癌发病的关联性,为制定防治措施提供科学依据。方法系统检索2016年5月前国内外发表的有关中国人群饮食因素与肝癌相关性的文献资料,对各因素与肝癌发病关系的OR值及95%CI进行统计分析。结果最终纳入46篇文献,累计病例11 613例,对照为12726例,葱蒜类、豆制品、蔬菜类、水果类、茶类、鱼类因素合并的OR值及95%CI均<1;干硬食品、高盐饮食、禽蛋类、霉变食品、烟熏食品、腌制食品、酒类、肥肉、生鱼类因素合并的OR值及95%CI均>1;动物肉类、油炸食品、酸醋食品与肝癌的无关。结论在中国人群饮食因素中,摄入葱蒜类、豆制品、蔬菜类、水果类、茶类、鱼类可能为肝癌的保护因素;摄入干硬食品、高盐饮食、禽蛋类、霉变食品、烟熏食品、腌制食品、酒类、肥肉类、生鱼类饮食可能为肝癌的危险因素;动物肉类、油炸食品、酸醋食品与肝癌的关联尚不能确定。

Objective To explore the potential relationship between dietary factors of Chinese people and liver cancer, and to provide scientific evidence for the prevention and management of the disease. Methods We searched and selected Chinese and English literatures on dietary factors of Chinese people with liver cancer from the inception to May 2016. Statistical analysis was conducted using Statal2.0. Results We identified 46 eligible studies which involved 11 613 cases of liver cancer and 12 726 cases in control group. The pooled OR values （95%CI） of shallot or garlic, bean products, vegetables, fruits, tea and fishes were all under than 1; the pooled OR values （95%CI） of dry hard foods, high salt diet, eggs, moldy foods, smoked foods, pickled foods, wine, fat meat and raw fish were all greater than 1. There was no significant relationship of animal meat, fried food, acid and vinegar foods with liver cancer. Conclusion Shallot or garlic, vegetables, bean products, vegetables, fruits, teas and fishes may be the protective factors of liver cancer among Chinese people, while rough foods, high salt diet, eggs, moldy foods, smoked foods, pickled foods, wine, fat meats and raw fishes are the risk factors; the association of liver cancer with animal meat, fried foods and vinegar foods is uncertain yet.