玛咖提取物对体育运动的抗疲劳作用

Protective effect of maca extract on sport fatigue

目的探讨玛咖提取物对体育运动的抗疲劳作用。方法 50只雄性Wistar大鼠随机分为,(1)对照组:正常饲养,不游泳,灌胃等量蒸馏水;(2)单纯游泳组:游泳,灌胃等量蒸馏水;(3)游泳+给药组:游泳,并分别灌胃玛咖提取物4.0、8.0和16.0 g/(kg·bw)。每组10只动物。采用循环水流自由游泳,给予大鼠4.0、8.0和16.0 g/(kg·bw)玛咖提取物,连续给药15 d,第16天采样测定肝过氧化脂质(LPO)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)和肝糖元水平。结果与单纯游泳组动物比较,给予玛咖提取物4.0、8.0和16.0 g/(kg·bw)15d后,大鼠下沉次数分别减少了27.44%、42.86%、64.11%(P<0.01),下沉前游泳时间和游泳总时间分别延长了18.99%、64.46%、90.69%和37.12%、56.23%、94.72%(P<0.01),LPO水平分别降低了31.31%、42.00%、56.95%(P<0.01),SOD、GSH-Px和肝糖原水平分别升高了25.92%,31.82%、62.09%,12.33%,23.01%、46.36%和17.83%、44.69%、62.99%(P<0.01)。结论玛咖提取物具有降低肝LPO水平,增加肝糖原水平,提高SOD、GSH-Px活性,增强运动耐力和抗疲劳作用。

Objective To study the effect of maca extract on sport fatigue and its antioxidant effect.Methods 50 healthy male Wistar rats were randomly divided into control group （normal breeding,without swimming,equal amount of distilled water for gavage）,simple swimming group （swimming,equal amount of distilled water for gavage）,swimming and medicine group （divided into maca extract 4.0,8.0 and 16.0 g/（kg· bw） groups,respectively）,10 rats in each group.All rats were freely swimming in the circulating water flow daily for 15 days.On the 16th day of experiment,liver tissue samples were collected.The liver lipid peroxide （LPO）,superoxide dismutase （SOD）,glutathione peroxidase （GSH-Px） and liver glycogen level were determined.Results When rats were administered with maca extract at the doses of 4.0,8.0,16.0 g/（kg· bw）,respectively,the swimming time before sinking and the total swimming time were increased by 18.99%,64.46% and 90.69%,and 18.99%,56.23% and 94.72%,respectively,while the numbers of times of sinking were decreased by 27.44%,42.86%,64.11% （P〈0.01）,respectively,compared with the swimming rats without maca extract treatment.The LPO content in the liver of rats treated with maca extract 4.0,8.0,16.0 g/（kg· bw） were reduced by 31.31%,42.00% and 31.31%,respectively,while the levels of SOD,GSH-Px and liver glycogen were enhanced by 25.92%,31.82%,62.09%,12.33%,23.01%,46.36% and 17.83%,44.69%,62.99%,respectively,over those of rats without maca extract treatment.Conclusions Maca extract reduces the liver LPO level,increases liver glycogen level,improves the SOD and GSH-Px activity,therefore,plays a protective role in sport fatigue.