反复自然流产与封闭抗体相关性的Meta分析

A Meta-analysis of RSA Associated with Blocking Antibody

目的采用Meta分析方法评价封闭抗体与反复自然流产的相关性。方法通过计算机检索中国知网、万方、维普和Medline数据库,收集1994年4月到2016年8月中国公开发表的所有关于封闭抗体与反复自然流产相关性的病例-对照研究,根据纳入和排除标准筛选文献,提取资料和质量评价,以合并比值比(odds ratio,OR)及其95%CI为效应指标,运用STATA12.0软件,进行Meta分析。结果经严格筛选后共纳入13篇文献,合计反复自然流产组5364例,对照组4774例。经Meta回归分析显示,反复自然流产组的封闭抗体阳性显著低于对照组[OR=0.09,95%CI=(0.04,0.21),P<0.05],其差异具有统计学意义。结论反复自然流产与封闭抗体缺乏有关,对有流产病史者进行封闭抗体检测,可为诊疗提供参考依据。

Objective To evaluate the association between the risk of recurrent spontaneous abortion（RSA）and blocking antibodies（BA）by Meta-analysis.Methods By searching CNKI,Wanfang,Vip,Medline database from April1994 to August 2016,all the case-control studies about the association between RSA and BA were collected.The established items were used for the standard of selection and quality assessment.STATA12.0was used to quantitative analyze the odds ratio（OR）and confidence interval（CI）.Results Through strict literature search,13 articles were selected,including 5364 patients with RSA and 4774 health pregnant woman as control group.The result indicated that BA for RSA was lower than the control group[OR=0.06,95% CI=（0.05,0.08）,P=0.000].Conclusion RSA is related to the lack of blocking antibodies.It can provide reference for the diagnous and treatment of the patients who have the history of abortion.