醴陵市首例人感染H7N9禽流感病例的流行病学调查和防控分析

Epidemiological Investigation and Prevention and Control Analysis of the First Human Infection of H7N9 Avian Influenza in Liling

目的对我市首例人感染H7N9进行流行病学调查,为今后制定人感染H7N9预防控制措施提供依据。方法采用流行病学调查方法,调查病例的发病经过、可能的感染来源、传播途径等。结果确诊1例,经救治无效后死亡。患者无明确的活禽接触史。患者的密切接触者中均未发现异常临床表现。在1~3月份15份污水和禽饮水标本检测检出7份H7N9禽流感病毒核酸阳性,禽类来源于外地州市或外省。结论活禽暴露是人感染H7N9禽流感病毒的关键风险因素,暂无确切证据人传人。需加大监测范围、时间和拓展血凝素基因分析。

Objective To investigate the epidemiology of the first human infection with H7N9 in our city, and to provide evidence for the prevention and control of H7N9 infection in the future. Methods Epidemiological investigation was conducted to investigate the course of the disease, the possible source of infection and the route of transmission. Results One cases was diagnosed and died after the treatment was invalid. The patient had no definite contact history with live birds. No abnormal clinical manifestations were found in the close contacts of the patients. From January to March, 15 samples of sewage and poultry water samples were detected, 7 positive for H7N9 avian influenza viruses, and avian origin from foreign states, cities or provinces. Conclusion Exposure to live birds is the key risk factor for human infection with H7N9 avian influenza virus, and there is no definite evidence for human to human transmission. We need to increase the monitoring range, time and extend the analysis of hemagglutinin gene.