摘要
埃博拉病毒(EBOV)是一种高度致命的烈性病毒,能够引起人类和灵长类动物发生埃博拉出血热,死亡率高达50%以上。2013年底以来,EBOV在西非蔓延,由于缺乏有效的治疗,已经夺去了数千人的生命。目前,在研的防治埃博拉病毒的药物主要包括疫苗、小分子药物和抗体等,其中小分子药物以其生产迅速、产量大、性质稳定的优点而备受关注。简述抗EBOV小分子化合物的最新研究进展。
Ebola virus （EBOV） is a deadly virulent virus that could cause Ebola hemorrhagic fever （EBHF） in humans and primates, with a mortality rate of over 50%. Since the end of 2013, EBOV has spread in West Africa. Due to the lack of effective treatment, EBOV has claimed thousands of lives. At present, investigational drugs for prevention or treatment of EBOV mainly include vaccines, small molecules drugs and antibodies. Small molecule drugs have drawn extensive attention because of its rapid production, high yield and chemical stablility. In this paper, the latest research progress in anti- EBOV small molecule compounds has been reviewed.
出处
《药学进展》
CAS
2017年第6期444-449,共6页
Progress in Pharmaceutical Sciences
关键词
埃博拉病毒
小分子化合物
研究进展
Ebola virus
small molecule compounds
research progress
