黏膜相关恒定T细胞水平在脓毒症患者中的临床意义

Clinical implications of circulating mucosal associated invariant T(MAIT) cells in septic patients

目的研究脓毒症患者外周血循环黏膜相关恒定T细胞(MAIT细胞)的数量及活化状态。方法使用流式细胞技术测定外周血MAIT细胞的数量、比例和CD69活化分子的表达。结果脓毒症患者在疾病早期外周血MAIT细胞数量显著下降;在入住ICU的第1天与第3天,脓毒症组患者MAIT细胞的CD69表达量维持在较高水平。结论严重感染为特征的患者外周血MAIT细胞数量显著减少提示可能会发生脓毒症。

Objective To investigate the number and activation status of circulating mucosal associated invariant T （MALT） cells in patients with sepsis. Methods Flow cytometric method was used to determine the number and percentage of MAlT cells and their expression of activation molecule CD69. Results The circulating MAIT cells dropped significantly at early stage of sepsis in septic patients. The MAIT cells in the sepsis group continued to express high levels of CD69 on day l and day 3 after admission to ICU. Conclusions Remarkable decrease of circulating MAIT cells may portend the possibility of sepsis in patients with severe infection.