原发性失眠患者基于静息态功能磁共振的脑岛功能连接异常区

Abnormal Functional Connectivity of Insular in Primary Insomnia Based on Resting-state fMRI Study

【目的】观察静息状态下原发性失眠患者(PI)脑岛功能连接异常。【方法】收集60例PI患者及60例年龄、性别、受教育程度均匹配的健康对照组,采集被试者静息态功能磁共振数据,结合功能连接(FC)分析方法,选取双侧脑岛为感兴趣区域,经双样本t检验,得出全脑范围内两组间脑岛功能连接存在差异的脑区。【结果】与正常对照组相比,PI组双侧脑岛存在多个脑区的功能连接异常,其中与左侧脑岛FC值升高的区域有左侧扣带中回,右侧内侧额上回,右侧顶下缘角回,FC减低的区域有左侧中央前回,右侧梭状回(P<0.05);与右侧脑岛FC值升高的区域有右侧扣带中回,右侧梭状回,右侧额中回,FC值减低的区域有右侧中央前回,右侧颞中回(P<0.05)。【结论】PI患者双侧脑岛与脑内多个脑区存在异常的功能连接。本研究从功能整合的角度为理解原发性失眠的发生提供了影像证据。

[Objective] To explore the activity aberration of primary insomnia （PI） patients with resting-state fMRI. [ Methods ] Resting-state fMRI datasets of 60 PI and 60 healthy controls were acquired. We investigated the cortical connectivity patterns of the insula in PI and independent-sample t-test were used to compare the brain activity abnormalities between two groups. [Results] In PI, we found enhanced connectivity between left insular with the left middle cingulate cortex , the FrontalSupMedia and right ParietalInf, as well as decreased connectivity with the left precentral gyrusand the right fusiformgyrus （P 〈 0.05 ）. The right insular show increased FC with the right middle cingulate cortex, the right fusiform gyrus and the fight middle frontal gyms, as well as decreased FC with the right precentral gyms and the fight middle temporal gyrus （ P 〈 0.05 ）. [ Conclusion ] This study provides additional evidence of brain functional integration alterations in PI. Those may help us understand the possible neural mechanisms of PI.