血红素加氧酶1与糖尿病肾病的研究进展

Research Progress of Heme Oxygenase-1 and Diabetic Kidney Disease

糖尿病肾病(DKD)是糖尿病的重要并发症之一,也是终末期肾脏疾病的最常见原因,其发病机制是多种致病因素共同作用的结果,其中氧化应激、炎症和纤维化是DKD发生、发展的关键环节。而血红素加氧酶1(HO-1)在调节氧化应激、抗炎、抗纤维化中至关重要,且在DKD患者和动物模型中发挥了肾脏保护作用。在DKD治疗靶点的探索中,大多数研究均集中在改善代谢产物水平异常方面,很少有关于HO-1作为内源性肾保护因素的报道。因此,HO-1为了解DKD的发生、发展提供了一个新视角,同时也可能成为未来DKD治疗的切入口。

Diabetic kidney disease （DKD） is an important diabetic complication and the most common cause of end stage renal disease. It has been recognized as a result of multiple pathogenic factors including oxidative stress,inflammation and fibrosis. The heme oxygenase-1 （ HO-1 ） plays an important role in regulating oxidative stress, anti-inflammation and anti-fibrosis. It is found to protect the kidney both in human and animal models. To identify targets for therapeutic intervention,most studies have focused on understanding how abnormal levels of such metabolites cause DKD. However, there have been few reports regarding the HO-1 as an endogenous renal protective factor. Therefore, HO-1 could be providing a new perspective for understanding the development of DKD, and might provide a new target in the treatment of DKD.