吸烟对不同病变支数冠心病患者下肢动脉硬化闭塞的影响

Influence of smoking on peripheral arterial occlusive disease patients with different bifurcation number of coronary artery lesion

目的探讨吸烟对不同病变支数冠心病患者下肢动脉硬化闭塞的影响。方法选择行冠状动脉造影检查的患者200例,按结果分为无冠心病的对照组和冠心病组,其中冠心病组患者又分为单支病变、两支病变、三支病变,每组各50例。分析患者吸烟与下肢动脉硬化闭塞情况及下肢动脉踝肱动脉压力指数(AAI)的关系。结果吸烟者中,冠心病患者的下肢动脉闭塞情况较非冠心病者的严重(P<0.05);非吸烟者中,冠心病患者的下肢动脉闭塞情况与非冠心病者无差异(P>0.05);随着冠状动脉病变支数增多,吸烟者AAI的降低幅度要大于未吸烟者(P<0.05)。结论吸烟对不同冠状动脉病变患者下肢动脉硬化闭塞较高,吸烟冠心病患者病变分支越多,其AAI值越低。

Objective To explore the influence of smoking on peripheral arterial occlusive disease patients with different bifurcation number of coronary artery lesion. Methods A total of 200 patients underwent coronary angiography were enrolled and were divided into control group and coronary heart disease group depending on whether they were suffering from coronary heart disease. The patients in the coronary heart disease group were divided into single-lesion group,two-lesion group and three-lesion group,with 50 cases in each group.The relationship of smoking with peripheral arterial occlusive disease and ankle-arm index（AAI） was analyzed in each group. Results Among smoking patients,patients with coronary heart disease had severer lower limb obliterans compared to patients without coronary heart disease（P〈0. 05）. Among non-smoking patients,there was no significant difference in the severity of lower limb obliterans between patients with coronary heart disease and patients without coronary heart disease（P〉0. 05）. As the bifurcation number of coronary lesions increased,the decrease of AAI in the smokers was more than that in the non-smokers（P〈0. 05）. Conclusion Smoking has an effect on peripheral arterial occlusive disease patients with different bifurcation number of coronary artery lesion. For smoking patients with coronary heart disease,the more coronary bifurcation lesions they have,the lower AAI they obtain.