血清Lp-PLA_2含量对早期无症状糖尿病周围神经病变的筛查价值

The value of serum lipoprotein associated phospholipase A_2 levels in screening patients with early asymptomatic diabetic peripheral neuropathy

目的:探讨血清脂蛋白相关磷脂酶A_2(Lp-PLA_2)浓度在早期无症状糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)中的诊断和筛查价值。方法:选择病程小于12个月的早期2型糖尿病患者89例,以神经肌电图检查为标准,将其分为DPN组和单纯糖尿病组。分别检测其血清Lp-PLA_2等血脂含量。用ROC曲线分析方法,评价Lp-PLA_2的诊断价值,并找出合适的截断点。结果:DPN组血清Lp-PLA_2浓度显著低于单纯糖尿病组(t=-3.772,P=0.000),ROC曲线下面积为0.731(P=0.001),说明Lp-PLA_2对DPN的诊断有意义,且当Lp-PLA_2浓度为133.50 ng/m L时最具有DPN诊断意义。结论:血清Lp-PLA_2浓度可能预测DPN,但仍需大样本研究进一步验证。

Objective： To investigate the value of the serum lipoprotein associated phospholipase A2（ Lp-PLA2） levels in the diagnosis and screening of early asymptomatic diabetic peripheral neuropathy（ DPN）. Methods： A total of 89 patients diagnosed with type 2 diabetes less than 12 months were divided into DPN group and non-DPN group according to neural electromyography. The diagnostic value of Lp-PLA2 by diagnostic test and ROC curve analysis were evaluated and the appropriate cut-off point were determined. Results： The level of serum Lp-PLA2 of DPN group was significantly lower than that of nonDPN group（ t =-3. 772,P = 0. 000）. The area under curve（ AUC） of Lp-PLA2 was 0. 731（ P =0. 001）. The appropriate cut-off point was 133. 50 ng/m L. Conclusion： Serum Lp-PLA2 levels could predict DPN,but which still need further to be validated in larger sample research.