辣木叶和种子的提取及急性毒性评价

The extraction and acute toxicity testing of Moringa oleiferaleaves and seeds

目的测试辣木叶和种子的急性毒性以及安全剂量范围。方法参照《中药药理研究方法学》设计实验,确定中药新药的最大耐受量和急性毒性。结果小鼠对辣木叶超微粉和辣木叶醇提物的最大耐受量分别为0.4g/20g、0.8g/20g,辣木叶超微粉和辣木叶醇提物的成人日剂量分别在10g/50kg、20g/50kg以下为安全剂量。结论辣木叶为较安全的药食两用植物,其药理作用值得进一步研究。

Objective To test the acute toxicity and determine the safe dose range of Moringaoleifera leaves and seeds . Methods Acute toxicity tests were performed based on the documented experimental designs in Research Methods of Pharma - cology of Chinese Traditional Medicine . Results The maximum tolerated dose of the superfine powder and alcoholic-aqueous extract of Moringaoleifera leaves were 0 .4 g/20 g and 0 .8 g/20 g for mice. The safe dose for human is under or equal to 10 g/50 kg and 20 g/50 kg . Conclusion Moringaoleif era leaves were safe for medical and food use . The further research and development is warranted for this plant .