基于T>MIC简易数学模型对二室模型的拓展适用性探讨美罗培南给药方案

Meropenem regimens based on the simple mathematical model of T>MIC for two-compartment model

目的考察T>MIC简易数学模型对二室模型的适用性,简化T>MIC计算过程,并据此探讨美罗培南给药方案。方法以美罗培南的推荐剂量和静脉输注时间分别为0.5h与3h设计6种临床常用方案(0.5g/次q8h0.5h、0.5g/次q8h3h、1.0g/次q8h0.5h、1.0g/次q8h3h、2.0g/次q8h0.5h、2.0g/次q8h3h),各方案分别与美罗培南对临床常见致病菌的4种MIC敏感性折点(0.5、1、2、4μg/ml)组合形成不同的T>MIC,每种方案的T>MIC又可根据简易模型和二室模型计算,结果形成不同方案下的T>MIC对子,T>MIC差异采用配对样本t检验,考察简易数学模型的拓展适用性。并根据简易模型计算T>MIC%,以其达到40%~100%探讨美罗培南对不同细菌感染的给药方案。结果与结论简易模型可替代二室模型计算T>MIC,根据该模型从理论上可方便快捷地对美罗培南给药方案进行初判和模拟优化。

Objective To simplify the calculation of T MIC and evaluate meropenem regimens based on the simple mathematical model of T〉MIC reported in literature for two-compartment model .Methods Six meropenem regimens were de-signed according to the recommended dose with the infusion duration of 0 .5 h and 3 h . Four different MIC susceptibility break-point of meropenem against clinical microbiologic flora were used to formulate different TMIC .Each TMIC was calculated by both the simple and two-compartment model of T〉MIC .Meropenem regimens were evaluated for different bacterial infec-tions based on the simple model of T〉MIC with 40% ？100% of the T〉MIC% as the target. The t-test suggested no signifi-cant difference between the pairs of TMIC calculated by the two models .Results and Conclusion Simple model of T〉MIC can replace the two-compartment model .Meropenem regimens can be optimized based on this simple model of TMIC conven-iently and quickly .