儿科患者使用奥司他韦的临床应用分析

Clinical Application of Oseltamivir to Pediatric Patients

目的了解肇庆市第二人民医院儿科患者应用奥司他韦的情况,评价其用药合理性,促进临床合理用药。方法采用回顾性调查方法,抽查我院普儿科2016年01月—2016年06月应用奥司他韦的病历,共226例,调查用药情况。结果本品以经验性用药为主,用法皆为每天2次,疗程以1~5天多见(189例,83.63%)。用量合理有81例(占35.84%),用量偏小136例(占60.18%)。本品单独应用仅4例,与抗病毒药联用73例次(28.73%),与抗菌药物联用22例次(8.67%),三者联用159例次(62.60%)。联用方案以联合喜炎平注射液(17.32%)最多。结论奥司他韦用药情况基本合理,但在剂量、疗程与联合用药方面存在不合理现象,需在这几方面加强用药监控。

Objective To analyze the use of oseltamivir in treatment of pediatric patients in Zhaoqing No. 2 Peopler s Hospital （referred to as our hospital） and evaluate its rationality so as to promote the properly clinical use of drugs. Meth-ods A retrospective method was conducted to investigate the oseltamivir use among 226 pediatric patients in our hospital from January 2016 to June 2016. Results Oseltamivir was empirically administered twice a day with mostly course of treat-ment ≤five days （189 cases, 83. 63% ） ; 81 cases used reasonable daily dosage （3 5 . 84% ） and 136 cases did under the dosage （60. 18% ） . 4 cases took Oseltamivir single, 73 case/time took it in combination with antiviral drugs （28. 73% ） and 22 in combination with antibacterials （8. 67% ） and 159 in combination with the mentioned three drugs （62. 60% ）. Xiyan- ping injection was the most common one in the combination （17. 32% ）. Conclusion The use of Oseltamivir is generally reasonable, but there are some irrational uses in view of the dosage, course of treatment and combination with other drugs. It is necessary to strengthen the drug monitoring in the three aspects.