细胞内锌稳态调控及其在胰腺癌发生发展过程中的作用

Regulation of intracellular zinc homeostasis: Role in occurrence and development of pancreatic carcinoma

锌参与300种以上的细胞生理过程,包括DNA及蛋白合成、酶的活化以及细胞内信号转导过程.同时锌也是许多酶类,如碳酸酐酶、基质金属蛋白酶的关键组分,而这些酶类与缺氧、血管生成、细胞增殖及肿瘤转移密切相关,因此,锌的获取对于恶性肿瘤的生长和进展非常重要.细胞内锌离子的浓度变化受到Zn T1、ZIP4、金属硫蛋白及金属转录因子1等的调控,细胞内锌稳态是多种调控机制参与下锌内流、锌外流和保留之间动态平衡的结果.已有大量研究证实锌稳态调控失衡与胰腺癌的发生和转移有关,因此,锌及锌稳态的调控异常在胰腺癌的发生发展中具有重要作用.

Zinc（Zn） is an essential micronutrient that is required in over 300 different cellular processes, including DNA and protein synthesis, enzyme activity, and intracellular signaling. Z n availability is also important for tumor growth and progression because it is an essential component for many enzymes such as carbonic anhydrase and matrix metalloproteinases, which are involved in hypoxia, angiogenesis, cell proliferation, and metastasis. Intracellular Zn homeostasis is tightly regulated through the integration of Zn transporting mechanisms, including zinc influx, efflux and intracellular retention. A large number of studies have confirmed that the deregulation of Zn homeostasis is related to the occurrence and metastasis of pancreatic carcinoma. Therefore, the abnormal regulation of intracellular zinc homeostasis plays an important role in the occurrence and development of pancreatic carcinoma.