调节GLUT4转位化合物及相关的信号通路研究进展

Drugs promoting GLUT4 translocation and related signaling pathways

葡萄糖转位载体4(GLUT4)转位的受损与2型糖尿病密切相关,所以筛选促进GLUT4转位的药物并研究其相关的信号通路对治疗2型糖尿病具有十分重要的意义。药物促进GLUT4转位主要通过AMP活化蛋白激酶(AMPK)、磷脂酰肌醇3激酶/蛋白激酶B(PI3K/Akt)和蛋白激酶C(PKC)信号通路。本文分别介绍了这三种信号通路与GLUT4转位的关系以及相关的促进GLUT4转位的药物,为寻找治疗2型糖尿病的潜在新药提供参考。

Reduced glucose transporter type 4（GLUT4） translocation from the intracellular pool to the plasma membranes is one of the important causes of insulin resistance in type 2 diabetes.And it is of great significance to screen new drugs promoting GLUT4 translocation and study related signaling pathways for the treatment of type 2 diabetes.Drugs that increase GLUT4 translocation are mainly involved in AMP activated protein kinase（AMPK）,phosphatidylinositol 3 kinase/protein kinase B（PI3K/Akt） and protein kinase C（PKC） signaling pathways.These signaling pathways and related drugs promoting GLUT4 translocation are introduced.This article provides a reference for potential new drugs for the treatment of type 2 diabetes.