胰岛素信号通路参与阿尔兹海默症发病机制的研究进展

Research progress on insulin signaling pathway involved in the pathogenesis of Alzheimer's disease

阿尔兹海默病(Alzheimer's Disease,AD)是一种以老年斑和神经纤维缠结为主要病理学特征的中枢神经系统退行性疾病,其发病机制极为复杂。胰岛素信号通路作为胰岛素生理作用中的主要信号传导途径,在代谢、神经保护和调节认知功能障碍等方面发挥着重要作用。研究显示AD患者常伴随着胰岛素信号通路障碍和胰岛素抵抗(insulin resistance,IR)等症状的发生,提示胰岛素信号通路可能与AD的发病过程密切相关。本文以胰岛素信号通路为切入点,阐述该通路参与AD发病的可能机制,以期为预防和治疗阿尔兹海默病提供新线索。

Alzheimer＇s disease（AD） is a chronic central nervous system degenerative disease,which is characterized by senile plaques and neurofibrillary tangles.The pathogenesis of AD is very complex.Insulin signaling pathway,which is the main signal transduction pathway in insulin physiological function,plays an important role in the metabolism,nerve protection and regulation of cognitive dysfunction,etc.Studies indicate that the symptoms of AD patients are always accompanied with insulin signaling pathway disorder and insulin resistance and other symptoms,which suggests that insulin signaling pathway is closely involved in the pathogenesis of AD.In this paper,we attempt to illustrate the possible mechanism of insulin signaling pathway involving in the pathogenesis of AD,and provide a new clue for the prevention and treatment of AD.