高血压脑白质疏松患者认知功能与神经生化指标的相关性

Correlations of cognitive function with nerve biochemical indicators in hypertensive patients with leukoaraiosis

目的:研究高血压脑白质疏松患者认知功能与IL-6、NSE、TNF-α、MMP-2之间的关系。方法:对满足入组条件的43例患者进行MMSE及Mo CA评分,按评分结果分正常组及异常组,所有入组者均采集血检测IL-6、NSE、TNF-α、MMP-2。比较两组间量表评分与神经生化指标之间的差异及其相关性。结果:(1)在高血压脑白质疏松患者中Mo CA量表评分异常组血清IL-6、TNF-α、MMP-2、NSE水平较正常组明显升高,差异有统计学意义(P<0.05);在MMSE评分组间差异无统计学意义(P>0.05)。(2)相关性分析提示IL-6、TNF-α、MMP-2与Mo CA评分呈负相关(P<0.05),且与MMP-2相关性最大(r=0.430)。结论:高血压脑白质疏松患者血清IL-6、TNF-α、MMP-2、NSE水平越高,则认知功能障碍程度越重,且MMP-2或可作为判断认知功能障碍的重要指标。

Objective： To investigate the correlations of cognitive function with IL-6,NSE,TNF-α and MMP-2 in hypertensive patients with leukoaraiosis. Methods： Mini-mental state examination（MMSE） and montreal cognitive assessment（Mo CA） were conducted in 43 hypertensive patients with leukoaraiosis who met the inclusion criteria,respectively. Based on MMSE and Mo CA score,they were divided into normal group and abnormal group. Blood samples were collected from all included patients for the detection of IL-6,NSE,TNF-α,and MMP-2. Scale scores and nerve biochemical indicators in the two groups were compared and their correlations were analyzed. Results：（1） In hypertensive patients with leukoaraiosis,serum IL-6,TNF-α,MMP-2 and NSE levels in abnormal Mo CA score group increased significantly as compared with normal Mo CA score group,presenting statistically significant differences（P〈0.05）. MMSE score showed no obvious difference between the two groups（P〈0.05）.（2）Correlation analysis revealed that blood biochemical indicators including IL-6,TNF-α and MMP-2 were negatively correlated with Mo CA score（P〈0.05）,with MMP-2 showing the maximum correlation（r = 0.430）. Conclusion： Higher serum IL-6,TNF-α,MMP-2 and NSE levels in hypertensive patients with leukoaraiosis are with severer cognitive dysfunction. In addition, MMP-2 may be used as an important indicator for determining cognitive dysfunction.