ICU真菌感染早期采用氟康唑经验性治疗效果观察

Effect observation of empirical and early treatment with Fluconazole on fungal infection of ICU

目的:探讨ICU真菌感染患者早期采用氟康唑经验性治疗效果。方法:选取ICU收治92例危重患者,随机分为研究组、对照组。研究组早期给予氟康唑经验性治疗,对照组患者经临床诊断,确诊为真菌感染后用氟康唑进行抗真菌治疗。比较两组真菌清除率、治疗效果及药物不良反应发生率。结果:研究组患者真菌清除率、治疗总有效率均高于对照组(88.89%比47.73%,97.83%比84.78%,P<0.05)。两组药物不良反应发生率比较无统计学意义(P>0.05)。结论:ICU真菌感染患者早期采用氟康唑经验性治疗可提高真菌清除率和治疗效果,具有较高的安全性。

Objective： To investigate the effect of empirical and early treatment with Fluconazole in patients with ICU fungal infection. Methods： 92 cases of critically ill patients received ICU were randomly divided into study group and control group. The study group was treated with Fluconazole in the early stage,while the control group was treated with Fluconazole after clinical diagnosis. The clearance rates,treatment effect and adverse drug reactions were compared between the two groups. Results： The fungal clearance rate and total effective rate in the study group were higher than those in the control group（88. 89% vs. 47. 73%,97.83% vs. 84. 78%,P〈0. 05）. There was no significant difference in the incidence of adverse drug reactions between the two groups（P〉0.05）. Conclusion： Early treatment with Fluconazole in patients with fungal infection of ICU can improve the rate of fungal clearance and treatment effect with the higher safety.