Spiro(phosphoamidite) ligand(SIPHOS)/Cu(OTf)2-catalyzed highly regio-and stereo-selective hydroborations of internal alkynes with diborane in water
Spiro(phosphoamidite) ligand(SIPHOS)/Cu(OTf)_2-catalyzed highly regio-and stereo-selective hydroborations of internal alkynes with diborane in water
摘要
The highly regio-and stereoselective hydroborations of unactivated internal alkynes with diboron compound catalyzed by Cu（OTf）2 with spiro（phosphoamidite） as ligand in the presence of Cs2CO3 in water was developed.This protocol was applied efficiently in the aqueous synthesis of multi-substituted vinylboranes.
The highly regio-and stereoselective hydroborations of unactivated internal alkynes with diboron compound catalyzed by Cu（OTf）2 with spiro（phosphoamidite） as ligand in the presence of Cs2CO3 in water was developed.This protocol was applied efficiently in the aqueous synthesis of multi-substituted vinylboranes.
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