摘要
Leonurine（1）,an important ingredient in leonurus sibiricus L,can be used for some gynecological disease.We have developed a concise and efficient synthetic route of Leonurine,which can be optimized for mass production.Commercially available compound 6 and 2,3-dihydrofuran（7） were used as starting materials.And the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.
Leonurine（1）,an important ingredient in leonurus sibiricus L,can be used for some gynecological disease.We have developed a concise and efficient synthetic route of Leonurine,which can be optimized for mass production.Commercially available compound 6 and 2,3-dihydrofuran（7） were used as starting materials.And the toxicity study on zebrafish shows that Leonurine would promote the hatching of zebrafish embryos at low concentration and result in acute death or chronic lethal toxicity at high concentration.
基金
supported by Anhui Ph.D.Programs of Postdoctoral Workstation,Talents Program of Hefei
funds from the sixth group of Anhui '115' Industrial Innovation Team(Team of Key Technology Innovation on Botanical Pesticides)
