^(18)F-FDG PET/CT显像特征与恶性淋巴瘤病理类型的相关性

^(18)F-FDG PET/CT Imaging Features in Different Pathological Types of Malignant Lymphoma

[目的]探讨 ^(18)F-FDG PET/CT显像特征与恶性淋巴瘤病理类型的关系。[方法]回顾性入组2013年1月至2016年6月 ^(18)F-FDG PET/CT显像考虑为淋巴瘤可能的74例患者(男性41例,女性33例),穿刺、手术病理明确最终诊断。分析 ^(18)F-FDG PET/CT诊断与病理诊断一致性。同时探讨PET/CT显像特征如是否伴脾大、结外侵犯、浅表及深部淋巴结累及、SUVmax等与病理类型的相关性。[结果]74例 ^(18)F-FDG PET/CT考虑为淋巴瘤可能的患者中,最终病理明确为淋巴瘤者占70.27%(52/74),淋巴瘤SUVmax明显高于非淋巴瘤(10.68±4.49 vs5.04±2.63,t=-5.490,P=0.001),其中HD占25.00%(13/52),NHL占75.00%(39/52)。HD组发病年龄小于NHL组(P=0.001);18F-FDG PET/CT显像HD组累及深部淋巴结及结外器官与NHL组相比,差异均有统计学意义(P=0.031,P=0.013);浅表淋巴结累及组间差异无统计学意义。NHL组SUVmax高于HD组(11.47±4.86 vs 8.55±2.29,Z=-2.188,P=0.029)。[结论]不同病理类型淋巴瘤 ^(18)F-FDG PET/CT显像特征不同,其中弥漫大B细胞淋巴瘤累及范围广泛,NK/T细胞淋巴瘤以累及鼻腔多见。

[Objective] To examine the characteristics of ^18F-FDG PET/CT findings in different pathologic types of malignant lymphoma. [Methods] Seventy four patients（41 males,33 females）with suspected malignant lymphoma on ^18F-FDG PET/CT imaging underwent biopsy and pathologic examination from January 2013 to June 2016. The features of PET/CT imaging in different pathological types of lymphoma were analyzed. [Results] Fifty two patients were diagnosed as malignant lymphoma by pathological examination（70.27%）,including 13 cases of Hodgkin＇s disease（HD） and 39 cases of non-Hodgkin＇s lymphoma（NHL）. The maximum standard uptake value（SUVmax） was significantly higher in lymphoma patients than that in non-lymphoma patients（10.68±4.49 vs 5.04±2.63,t=-5.490,P=0.001）. Compared to the NHL,the age of HD patients was significantly lower（P=0.001）. There was significant difference in the involvement of external organs and deep lymph nodes between two groups（P=0.031,P=0.013）,but no difference in superficial lymph node involvement. SUVmax was higher in NHL group than that in HD group（11.47±4.86 vs 8.55±2.29,Z =-2.188,P =0.029）. [Conclusion] The features ^18F-FDG PET/CT imaging in Hodgkin＇s lymphoma are different from those in non-Hodgkin＇s lymphoma.