手足口病患儿T淋巴细胞亚群与NK细胞和血清白细胞介素、TNF-α变化的研究

Study on the changes of T lymphocyte subsets,NK cells,serum interleukins and TNF-α in children with hand-foot-and-mouth disease

目的观察手足口病患儿T淋巴细胞亚群与NK细胞和血清白细胞介素、TNF-α的变化情况。方法选取在医院进行诊治的100例手足口病患儿为观察组,同时期的100例体检健康儿童为对照组,检测与比较两组儿童的外周血T淋巴细胞亚群与NK细胞和血清白细胞介素、TNF-α水平,同时比较不同严重程度、感染类型及分期手足口病患儿的上述指标检测水平。结果观察组患儿的T淋巴细胞亚群与NK细胞和血清白细胞介素、TNF-α均差于对照组儿童,且不同严重程度及分期手足口病患儿的检测结果差异有统计学意义(P<0.05),而不同感染类型手足口病患儿的检测结果则差异无统计学意义(P>0.05)。结论手足口病患儿T淋巴细胞亚群与NK细胞和血清白细胞介素、TNF-α的表达相对较差,且严重程度及分期是对其表达影响较大的因素,应重视对手足口病患儿进行上述指标的监测与调节。

Objective To observe the changes of T lymphocyte subsets,NK cells,serum interleukins and tumor necrosis factor-α（TNF-α） in children with hand-foot-and-mouth disease（HFMD）.Methods One hundred children with HFMD treated in the hospital were selected as observation group,and one hundred healthy children during the same period were selected as control group.The levels of T lymphocyte subsets,NK cells in peripheral blood,interleukins and TNF-α in serum were detected and compared between the two groups.The levels of above-mentioned indexes were compared among the children with different degrees of severity,infection types and stages of HFMD.Results The levels of T lymphocyte subsets,NK cells in peripheral blood,interleukins and TNF-α in serum in observation group were statistically significantly lower than those in control group,and there were statistically significant differences among the children with different degrees of severity and infection stages of HFMD（P〈0.05）,but there was no statistically significant difference among the children with different infection types of HFMD（P〉0.05）.Conclusion The levels of T lymphocyte subsets,NK cells in peripheral blood,interleukins and TNF-α in HFMD children are relatively low,the degree of severity and infection stages of HFMD are influencing factors,monitoring and regulation of the above-mentioned indexes should be paid more attention to among HFMD children.