运动激活AMPK减少海马Aβ沉积的可能机制

The possible mechanism of AMPK-mediated hippocampal Aβ deposition decrease by physical exercise

淀粉样蛋白(β-amyloid,Aβ)沉积形成的老年斑是阿尔茨海默病(Alzheimer’s disease,AD)最主要的病理原因之一,其海马内的异常沉积可诱导AD的发病,这与AD动物海马内腺苷酸活化蛋白激酶(AMPK)活性的降低有关。研究发现,适宜的体育运动能够抑制AD动物海马内Aβ的沉积,但具体机制尚不明确。现综述了近期的研究成果,推测适宜的体育运动可以通过消耗ATP,使AMP水平升高,AMP可激活海马内AMPK,激活了的AMPK可通过上调α-分泌酶表达和下调β-分泌酶表达来减少Aβ的生成,从而起到了预防和缓解AD的作用。

Deposition of hippocampal β-amyloid（Aβ） to form senile plaque is one of the most important pathological reasons of Alzheimer＇s disease（AD）. The abnormal deposition of Aβ in hippocampus may induce the development of AD, which might be related to the decrease of AMPK activity in hippocampus of AD animals. It was found that appropriate physical exercise might inhibit the deposition of Aβ in hippocampus of AD animals, but the mechanism was not clear. This paper reviews the recent research achievements and infers that suitable physical exercise can consume ATP to increase AMP. AMP can activate AMPK in hippocampus. The activated AMPK may up-regulate α-secretes and down-regulate β-secretes to reduce the formation of Aβ, thus preventing and alleviating AD.