盆腔器官脱垂及压力性尿失禁的相关因素分析

Relative Factors Analysis for Pelvic Organ Prolapse and Stress Urinary Incontinence

目的:探讨盆腔器官脱垂及压力性尿失禁的相关危险因素。方法:选择2007年1月至2016年1月在郑州大学第三附属医院盆底重建科行盆底重建术患者625例,将其中盆腔器官脱垂患者454例为A组,压力性尿失禁患者171例为B组,另选择体检的健康女性449例为对照组。分别统计分析其孕产次,是否绝经,有无子宫切除、慢性高血压、糖尿病、会阴裂伤、子宫肌瘤及阴道分泌物分析结果等资料,并进行单因素和多因素Logistic回归分析。结果:单因素分析示:A组子宫切除、已绝经、会阴裂伤患者所占比例均明显高于对照组(P<0.05);B组慢性高血压、会阴裂伤的患者所占比例均明显高于对照组(P<0.05);A组、B组多孕次(≥3次)、多产次(≥3次)患者所占比例高于对照组(P<0.05),存在乳杆菌患者所占比例低于对照组(P<0.05)。多因素Logistic回归分析示:子宫切除、已绝经、会阴裂伤、孕次≥3次、产次≥3次是盆腔器官脱垂的独立危险因素;会阴裂伤、孕次≥3次、产次≥3次是压力性尿失禁的独立危险因素。存在乳杆菌是盆底器官脱垂和压力性尿失禁的保护因素。结论:子宫切除、多孕、多产、会阴裂伤可能参与了盆腔器官脱垂及压力性尿失禁的发生发展,阴道乳杆菌的存在可能减少盆腔器官脱垂及压力性尿失禁的发生。

Objective：To explore the risk factors of pelvic organ prolapse and stress urinary incontinence factors. Methods：A total of 625 patients,who undergone surgery for pelvic floor reconstuction from January 2007 to January 2016 in the Third Affiliated Hospital of Zhengzhou University,were enrolled for this study. Among which 454 cases of pel- vic organ prolapse were assigned as group A,and 171 cases of stress urinary incontinence were assigned as group B. Meanwhile,449 female healthy subjects were selected as control group. The data including the times of gestation and parity,history of menopause, hysterectomy surgery, chronic hypertension, diabetes mellitus, history of perineal lacera- tion, uterine fibroid and leucorrhea were recorded and analyzed by single factor analysis and multi-factor Logistic repres- sion analysis. Results：Single factor analysis showed that the proportion of patients in group A who had the history of hysterectomy, menopause and perineal lacerationwas significantly higher than the control group（ P 〈0. 05）. The propor- tion of patients in group B who had the history of menopausal, hypertension,perineal laceration was significantly higher than the control group（P〈0. 05）. The proportion of patients in goup A and B who had the existence of lactobacillus, more times of gestation and paritywere significantly higher than the control group （ P 〈 0. 05）. Multi-factors analysis showed that the history of hysterectomy, menopause,perineal laceration, gravidity idity, parity are independent risk fac- tors for pelvic organ prolapse;perineal laceration,gravidity,parity are independent risk factors for stress urinary inconti- nence. The existence of lactobacillus in the vagina is a protective factors for stress urinary incontinence and pelvic organ prolapse. Conclusions.The history of hysterectomy, more times of gestation and parity, perineal laceration and lack of lactobacillus may be involved in the development of pelvic organ prolapse and stress urinary incontinence. The exist- ence of lactobacillus in the vagina is a protective factor.